Demonstrates a green method to synthesize di‐2‐pyranones in water, suggesting a more efficient approach to chemical synthesis.
A facile and environmentally friendly method for synthesizing di‐2‐pyranone derivatives via a three‐component reaction operating without catalysts or additives has been developed. This method uses readily available and cost‐effective starting materials and is carried out in water under microwave irradiation. A diverse range of di‐2‐pyranones (22 examples) was successfully prepared with high efficiency, demonstrating excellent substrate compatibility. The protocol offers several advantages, including a one‐pot operation, rapid reaction process, straightforward synthesis and purification steps, and elimination of any external catalytic systems or auxiliary substances.
No takes yet. Share an insight, caveat, or question.
Weng et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: