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March 10, 2026Journal of Biomedical Informatics1 citationsOpen Access

Model Utility And Explainability In Federated Learning For Healthcare

Model utility and explainability in federated learning - A case study in healthcare using fundus oculi datasets

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Authors

NPNiklas PenzelDSDaniel ScheligaHOHannes Oppermann

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Overview

Case study evaluates federated learning improvements in medical feature relevance and predictive power.

Key Points

  • Assess the effectiveness and explainability of federated learning methods in healthcare settings.
  • Combined six fundus oculi datasets to simulate diverse federated learning environments
  • Evaluated three federated learning methods against centrally trained models
  • Applied explainability techniques to analyze model features and local explanations
  • Achieved up to 9.97% improvement in model utility with federated learning methods
  • Identified vertical cup-to-disc ratio as a key feature for glaucoma diagnosis
  • Demonstrated robustness against biases in fundus datasets
  • Established high agreement between local explanations and ophthalmologist-annotated attention maps

Cite This Study

Penzel et al. (2026) studied this question.

synapsesocial.com/papers/69af957570916d39fea4d190https://doi.org/10.1016/j.jbi.2026.105010
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