Molecular Mechanisms of FAT Atypical Cadherin 1 (FAT1), the Hippo Pathway, and the Yes-Associated Protein (YAP) Signaling Pathways in Some Cancers

Roland Osei Saahene; Precious Barnes; Du-Bois Asante; Sylvester Ackah Famieh; Elvis Agbo

doi:10.31557/apjcp.2026.27.3.793

March 1, 2026Asian Pacific Journal of Cancer PreventionOpen Access

Molecular Mechanisms of FAT Atypical Cadherin 1 (FAT1), the Hippo Pathway, and the Yes-Associated Protein (YAP) Signaling Pathways in Some Cancers

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Key Points

The central aim is to explore the roles of FAT1, Hippo, and YAP pathways in cancer through mutations and expression changes.
Review of existing literature on FAT1, Hippo, and YAP gene functions.
Analysis of the impact of mutations on signaling mechanisms in cancer types.
Discussion of expression levels in relation to tumor behavior.
FAT1 mutations are linked to altered signaling pathways in specific cancers.
Hippo pathway dysfunction contributes to cancer progression through YAP activation.
Dysregulation of gene expression in these pathways promotes tumor formation.

Implication

This review uncovers the role of FAT1, Hippo, and YAP pathways in cancer, suggesting critical molecular interactions and impacts.

Abstract

This review discusses the FAT1, Hippo and Yap genes, with a focus on their mutations and expression levels, and their impact on signaling pathways and mechanisms in various types of cancer.

Discussion

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Cite This Study

Saahene et al. (2026) studied this question.

synapsesocial.com/papers/69af95c070916d39fea4db92 https://doi.org/10.31557/apjcp.2026.27.3.793

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Molecular Mechanisms of FAT Atypical Cadherin 1 (FAT1), the Hippo Pathway, and the Yes-Associated Protein (YAP) Signaling Pathways in Some Cancers

Key Points

Implication

Abstract

Discussion

Cite This Study

Molecular Mechanisms of FAT Atypical Cadherin 1 (FAT1), the Hippo Pathway, and the Yes-Associated Protein (YAP) Signaling Pathways in Some Cancers

Key Points

Implication

Abstract

Discussion

Cite This Study

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