Molecular Mechanisms of FAT Atypical Cadherin 1 (FAT1), the Hippo Pathway, and the Yes-Associated Protein (YAP) Signaling Pathways in Some Cancers

Key Points

• The central aim is to explore the roles of FAT1, Hippo, and YAP pathways in cancer through mutations and expression changes.
• Review of existing literature on FAT1, Hippo, and YAP gene functions.
• Analysis of the impact of mutations on signaling mechanisms in cancer types.
• Discussion of expression levels in relation to tumor behavior.
• FAT1 mutations are linked to altered signaling pathways in specific cancers.
• Hippo pathway dysfunction contributes to cancer progression through YAP activation.
• Dysregulation of gene expression in these pathways promotes tumor formation.