Albiflorin Relieves Intervertebral Disc Degeneration Through Inhibiting Nucleus Pulposus Cell via the p38 MAPK/NF‐κB Pathway

Kai Yang; Yanping Cheng; Dan Yang

doi:10.1002/iid3.70360

March 1, 2026Immunity Inflammation and DiseaseOpen Access

Albiflorin Relieves Intervertebral Disc Degeneration Through Inhibiting Nucleus Pulposus Cell via the p38 MAPK/NF‐κB Pathway

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Key Points

Investigate how albiflorin affects nucleus pulposus cells in intervertebral disc degeneration.
Examined the effects of albiflorin on nucleus pulposus cell function
Assessed apoptosis rates and inflammatory responses
Analyzed extracellular matrix degradation through biochemical assays
Albiflorin reduced apoptosis in nucleus pulposus cells
It lowered the inflammatory response markers
Decreased extracellular matrix degradation observed through assays

Implication

Intervertebral disc degeneration is alleviated by albiflorin, indicating its potential as a therapeutic agent.

Abstract

AF relieved IDD through repressing NP cell apoptosis, inflammatory response, and ECM degradation through the p38 MAPK/NF-κB pathway, indicating that it is a potential IDD therapeutic agent.

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69af95cf70916d39fea4dd66 https://doi.org/10.1002/iid3.70360

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Albiflorin Relieves Intervertebral Disc Degeneration Through Inhibiting Nucleus Pulposus Cell via the p38 MAPK/NF‐κB Pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

Albiflorin Relieves Intervertebral Disc Degeneration Through Inhibiting Nucleus Pulposus Cell via the p38 MAPK/NF‐κB Pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

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