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Carnosine activates a protective pathway against high glucose-induced pyroptosis in renal tubular cells, suggesting potential therapeutic benefits.
Carnosine protects renal tubular cells from high glucose-induced injury by alleviating mitochondrial oxidative stress and subsequent NLRP3 inflammasome-mediated pyroptosis through the activation of the AMPK/SIRT3/SOD2 signaling pathway. This activation is likely mediated by carnosine's ability to restore cellular bioenergetics.
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Zhao et al. (2026) studied this question.
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