In vitro and in vivo analysis demonstrates enhanced alveolar bone regeneration in periodontitis using zinc-loaded membranes, suggesting a new treatment strategy.
Key Points
The study aims to explore the effects of zinc-loaded membranes on immunomodulation and osteogenesis for alveolar bone regeneration in periodontitis.
Developed zinc-loaded polycaprolactone fibrous membranes via electrospinning and crystallization.
Examined macrophage polarization and bone marrow stem cell differentiation in vitro.
Assessed the regeneration of alveolar bone in vivo by evaluating immune microenvironments.
Zn 2+ leads to M2 macrophage polarization while inhibiting M1 polarization.
Enhanced osteogenic differentiation observed in bone marrow mesenchymal stem cells.
The membranes effectively remodel the immune microenvironment, boosting bone regeneration.