Inside Front Cover: Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function

Ketone body metabolism induces a previously unrecognized cysteine crotonation (Ccr) in mitochondrial proteins via a crotonyl intermediate. In the Research Article (e19830), Zhipeng A. Wang and co-workers reveal that Ccr at PRDX3 C229 disrupts redox regulation, leading to elevated reactive oxygen species. By integrating metabolic labeling with chemical proteomics, the work uncovers a new mechanism linking ketogenesis to mitochondrial redox signaling.