The research demonstrates the role of SLIT3/ROBO1 in enhancing angiogenic-osteogenic coupling in endothelial progenitor cells and mesenchymal stem cells, suggesting implications for vascularization.
EPCs/PBMSCs sheets ameliorate the limitations of early vascularization in PTE and the SLIT3/ROBO1 axis mediates the angiogenic-osteogenic coupling of EPCs/PBMSCs sheets, thereby augmenting their osteogenic effects.
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Rong et al. (2026) studied this question.
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