Antioxidant and anti-inflammation effects of Oxyspora howellii Jeffrey & W.W.Sm. extracts through regulation of NF-κB signaling pathway

Key Points

• The study aims to evaluate the antioxidant and anti-inflammatory effects of Oxyspora howellii extracts using RAW 264.7 macrophages.
• Utilized RAW 264.7 macrophages to assess effects of Oxyspora howellii extracts (OHE)
• Evaluated NF-κB signaling pathway activation in response to LPS stimulation
• Measured NO production and iNOS expression as indicators of inflammation
• Assessed mRNA expression levels of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6
• OHE significantly reduced NO production and iNOS expression in LPS-stimulated macrophages
• OHE inhibited the overactivation of the NF-κB pathway
• OHE decreased mRNA levels of inflammatory cytokines in a concentration-dependent manner