Pilot study shows that adding testosterone treatment improves weight loss and health in obese men, suggesting a new treatment approach.
Our preliminary findings suggest that adding TRT to tirzepatide in late tirzepatide responders who are hypogonadal may optimize weight loss quality, prevent muscle depletion, and restore sexual and metabolic health. This dual pharmacological approach represents a promising precision medicine strategy for managing complex phenotypes of male obesity-associated hypogonadism.
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Seminara et al. (2026) studied this question.
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