Nocturnal dexmedetomidine infusion versus placebo for prevention of postoperative delirium in elderly patients undergoing hip-fracture surgery: a protocol for a multicentre, randomized, double-blind trial

March 9, 2026TrialsOpen Access

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Key Points

To evaluate the efficacy of nocturnal dexmedetomidine infusion in preventing postoperative delirium in elderly patients undergoing hip-fracture surgery.
Multicentre, randomized, double-blind trial design
Comparison between dexmedetomidine infusion and placebo
Involves elderly patients undergoing hip-fracture surgery
Assessment of delirium occurrences post-surgery
Expected findings on the prevalence of postoperative delirium
Comparison of delirium rates between dexmedetomidine and placebo groups
Potential reduction in delirium symptoms with dexmedetomidine

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Multicentre trial examines dexmedetomidine's effect on delirium in elderly hip-fracture patients, suggesting potential benefits.

Chinese Clinical Trial Registry ChiCTR2400087107. Registered on 19 July 2024.

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Song et al. (2026) studied this question.

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