Experimental findings reveal ARPC1B influences tumor growth in gastric cancer by stabilizing HK2 mRNA via IGF2BP3, indicating a therapeutic target.
ARPC1B drives GC progression by stabilizing HK2 mRNA through IGF2BP3 binding, thereby potentiating glycolytic reprogramming to facilitate tumor growth and metastasis. Targeting the ARPC1B-IGF2BP3-HK2 axis may represent a novel therapeutic strategy for GC.
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Ma et al. (2026) studied this question.
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