16S rRNA Amplicon Sequencing of the Intraoperative Surgical Site Demonstrates an Aberrant Microbiota Which Can Predict Colorectal Surgical Site Infection

Veral Vishnoi; Emily C. Hoedt; Michelle Zhao; R. Carroll; Shaveen Kanakaratne; Natalie Lott; Peter Pockney; Spencer Smith; Simon Keely

doi:10.1111/ans.70578

March 9, 2026ANZ Journal of SurgeryOpen Access

16S rRNA Amplicon Sequencing of the Intraoperative Surgical Site Demonstrates an Aberrant Microbiota Which Can Predict Colorectal Surgical Site Infection

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Key Points

The research aims to identify the relationship between intraoperative microbiota and the development of surgical site infections.
Conducted 16S rRNA amplicon sequencing on intraoperative surgical site samples.
Analyzed microbiota composition in relation to subsequent infection outcomes.
Assessed the predictive power of identified microbiota patterns for infection.
Identified distinct aberrant microbiota associated with surgical site infections.
Demonstrated a correlation between specific microbiota profiles and infection risk.
Findings suggest potential for preemptive interventions based on microbiota analysis.

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Implication

Demonstrates aberrant microbiota predicts surgical site infection in colorectal patients, suggesting new prevention strategies.

Abstract

To the best of our knowledge this is the first study to demonstrate an aberrant intraoperative microbiota of the surgical site associated with subsequent infection. Pending validation studies, this provides a target for the strategic manipulation of the surgical site to reduce the burden of infection.

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Vishnoi et al. (2026) studied this question.

synapsesocial.com/papers/69b257bf96eeacc4fcec6ad6 https://doi.org/10.1111/ans.70578

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16S rRNA Amplicon Sequencing of the Intraoperative Surgical Site Demonstrates an Aberrant Microbiota Which Can Predict Colorectal Surgical Site Infection

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

16S rRNA Amplicon Sequencing of the Intraoperative Surgical Site Demonstrates an Aberrant Microbiota Which Can Predict Colorectal Surgical Site Infection

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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