Salvianolic acid B attenuates post-cardiac arrest cerebral ischemia–reperfusion injury via activation of the Nrf2 signaling pathway

Chuanbao Lv; Guangsheng Guo; Bo Feng; Shasha Yu

doi:10.1186/s40001-026-04177-3

March 9, 2026European journal of medical researchOpen Access

Salvianolic acid B attenuates post-cardiac arrest cerebral ischemia–reperfusion injury via activation of the Nrf2 signaling pathway

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Key Points

The aim is to evaluate how salvianolic acid B protects against neurological injury after cardiac arrest by targeting the Nrf2 pathway.
Evaluated the effects of salvianolic acid B on oxidative stress and inflammation levels after cardiac arrest.
Assessed neurological outcomes following cerebral ischemia-reperfusion injury (CI/R) in experimental models.
Analyzed the role of the Nrf2 signaling pathway in mediating protective effects.
Salvianolic acid B significantly reduced levels of oxidative stress and inflammation.
Marked decrease in apoptosis was observed in neuronal cells exposed to CI/R injury.
Activation of the Nrf2 pathway was confirmed, correlating with improved neurological outcomes.

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Implication

An intervention using salvianolic acid B reduces neurological injury in post-cardiac arrest, suggesting therapeutic potential.

Abstract

SalB protects against CI/R-induced neurological injury by reducing oxidative stress, inflammation, and apoptosis through Nrf2 activation, supporting its potential as a therapeutic agent for post-CA cerebral injury.

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Cite This Study

Lv et al. (2026) studied this question.

synapsesocial.com/papers/69b257bf96eeacc4fcec6af1 https://doi.org/10.1186/s40001-026-04177-3

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Salvianolic acid B attenuates post-cardiac arrest cerebral ischemia–reperfusion injury via activation of the Nrf2 signaling pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Salvianolic acid B attenuates post-cardiac arrest cerebral ischemia–reperfusion injury via activation of the Nrf2 signaling pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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