Validation of a metabolic risk calculator finds high risk in young adults with psychosis, suggesting improved assessment tools are needed.
Background and ObjectivesPeople with psychotic disorders have high cardiometabolic risk, yet prediction tools are rarely validated outside early-intervention settings.We externally validated and recalibrated the UK Psychosis Metabolic Risk Calculator (PsyMetRiC) in a Dutch cohort of young adults with psychotic disorders in long-term care. MethodsWe used data from the PHAMOUS registry.Individuals aged 16-35 years, without metabolic syndrome (MetS) at baseline (prevalence 21.2%), were included.MetS incidence over approximately six years (last assessment 1-6 years; cumulative incidence 29.1%) was defined using international criteria.Full (biochemical + clinical) and partial (clinical only) PsyMetRiC models were applied to 10 multiply imputed datasets.Discrimination, calibration, and decision-curve analysis (DCA) were assessed before and after logistic recalibration of intercept and slope.
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