This analysis shows HPV testing effectively detects disease recurrence post-conization, suggesting a reliable follow-up tool for women.
Using HPV testing as a stand-alone test after conization demonstrates an NPV nearly equal to that of the Test of Cure. Adding free margins to HPV testing further enhanced sensitivity and NPV for detecting CIN1+ persistence or relapse during follow-up. Our results indicate that HPV testing alone can be used as post-conization follow-up for women with negative margins.
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Alaref et al. (2026) studied this question.
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