Findings reveal that CUL5 regulation of cellular signaling is influenced by its neddylation status, suggesting broader implications.
These findings suggest that modification of CUL5 by NEDD8 may occur at multiple lysine residues and that multi-site neddylation may contribute to the diverse regulatory effects of CUL5 on cellular signaling and proliferation.
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Sundquist et al. (2026) studied this question.
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