Risk of Breast and Ovarian Cancer After Prophylactic Mastectomy and Salpingo‐Oophorectomy in BRCA1 /2 Germline Variant Carriers: A Retrospective Cohort Study From a Single German Center

Sara Mendes; Maryam Yahiaoui‐Doktor; Eva Maria Fallenberg; Marion Kiechle; Sabine Grill

doi:10.1002/cam4.71691

March 1, 2026SHILAP Revista de lepidopterologíaOpen Access

Risk of Breast and Ovarian Cancer After Prophylactic Mastectomy and Salpingo‐Oophorectomy in BRCA1 /2 Germline Variant Carriers: A Retrospective Cohort Study From a Single German Center

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Key Points

The study aims to evaluate the effectiveness of prophylactic surgeries in reducing cancer risk for BRCA1/2 variant carriers.
Conducted a retrospective cohort study at a single German center.
Assessed outcomes of prophylactic mastectomy and salpingo-oophorectomy.
Compared ipsilateral cancer prevalence between mastectomy and breast-sparing surgery.
Prophylactic surgeries showed high oncological effectiveness in germline variant carriers.
Mastectomy provided greater protection against ipsilateral cancer compared to breast-conserving surgery.
Further studies are needed to explore cancer prevalence differences.

Implication

Retrospective cohort study examines cancer risk after surgery in BRCA1/2 carriers, suggesting effective protection.

Abstract

Prophylactic surgeries demonstrate high oncological effectiveness in gPV BRCA1/2 carriers. In particular, mastectomy may provide greater protection against ISC compared with BCS. Further studies will have to be conducted to compare ipsilateral cancer prevalence after breast-sparing surgery and mastectomy.

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Cite This Study

Mendes et al. (2026) studied this question.

synapsesocial.com/papers/69b257fc96eeacc4fcec71ea https://doi.org/10.1002/cam4.71691

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Risk of Breast and Ovarian Cancer After Prophylactic Mastectomy and Salpingo‐Oophorectomy in BRCA1 /2 Germline Variant Carriers: A Retrospective Cohort Study From a Single German Center

Key Points

Implication

Abstract

Discussion

Cite This Study

Risk of Breast and Ovarian Cancer After Prophylactic Mastectomy and Salpingo‐Oophorectomy in BRCA1 /2 Germline Variant Carriers: A Retrospective Cohort Study From a Single German Center

Key Points

Implication

Abstract

Discussion

Cite This Study

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