52P Multiomic analysis of sinonasal intestinal type adenocarcinoma reveals distinct molecular signatures for tubulopapillary and mucinous subtypes

A. Franchi; Giorgia Arcovito; Iacopo Dallan; M. Morelli; F. Lessi; Paolo Aretini; C.M. Mazzanti

doi:10.1016/j.esmorc.2026.100258

March 1, 2026ESMO rare cancers.Open Access

52P Multiomic analysis of sinonasal intestinal type adenocarcinoma reveals distinct molecular signatures for tubulopapillary and mucinous subtypes

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Key Points

The analysis aims to uncover new prognostic factors associated with survival in sinonasal intestinal-type adenocarcinoma.
Retrospective assessment of 94 patients with confirmed intestinal-type adenocarcinoma between 1994-2024.
Inclusion criteria consisted of histological confirmation and complete clinical data.
Survival was evaluated using the Kaplan-Meier method and log-rank test for group comparisons.
Median follow-up reached 91 months, with a cohort primarily consisting of men aged 66 on average.
Recurrence occurred in 44% of case subjects, primarily locally, with median recurrence time at 99 months.
Factors indicating poor prognosis included dural invasion, orbital invasion, advanced stage, and mucinous histotype, among others.
Radical surgery at relapse demonstrated a 3.3-fold increase in survival.

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Implication

Retrospective analysis identifies prognostic factors influencing survival in intestinal-type adenocarcinoma, suggesting surgical intervention may improve outcomes.

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Franchi et al. (2026) studied this question.

synapsesocial.com/papers/69b257fc96eeacc4fcec731c https://doi.org/10.1016/j.esmorc.2026.100258

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52P Multiomic analysis of sinonasal intestinal type adenocarcinoma reveals distinct molecular signatures for tubulopapillary and mucinous subtypes

Key Points

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Implication

Discussion

Cite This Study

52P Multiomic analysis of sinonasal intestinal type adenocarcinoma reveals distinct molecular signatures for tubulopapillary and mucinous subtypes

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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