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March 1, 2026Cell Reports MedicineOpen Access

LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling

Lizhou Lin Xiao Li Wenyun Guo Jirong Xie Xiaolong Li Xin Guan Chongke Zhao Haohao Yin Huixiong Xu

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Key Points

The aim is to explore how engineered bacteria can alter immunosuppressive niches using mechano-NOTCH signaling.
Development of LIFUS-driven engineered bacteria
Assessment of immunosuppressive niche reprogramming
Analysis of mechano-NOTCH signaling pathways
Engineered bacteria effectively reprograms immunosuppressive environments.
Mechano-NOTCH signaling pathways are significantly activated.
Potential therapeutic implications for enhancing immune responses observed.

Implication

Engineered bacteria reprogram immunosuppressive environments via mechano-NOTCH signaling, indicating novel therapeutic potential.

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Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/69b2580996eeacc4fcec7457 https://doi.org/10.1016/j.xcrm.2026.102658

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