Bioinformatics study identifies candidate genes mediating obesity's effect on hepatocellular carcinoma, suggesting therapeutic targets.
ACAA1 and potentially ADI1 are downregulated candidate genes linking obesity to HCC. Their suppression likely drives obesity-related HCC progression by coupling mitochondrial metabolic reprogramming with immunosuppressive tumor microenvironment remodeling, representing potential therapeutic targets.
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Li et al. (2026) studied this question.
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