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March 12, 2026Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy0 citations

Effectiveness of Stimulant Treatment in Preventing Fractures and Head Injuries in Patients With Narcolepsy: A Self‐Controlled Case Series Study

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YZYunlong ZhengKyoto UniversityTFToshiki FukasawaKyoto UniversitySMSoichiro MasudaKyoto University

Key Points

  • The aim is to evaluate the impact of stimulant treatment on the risk of fractures and head injuries in narcolepsy patients.
  • Self-controlled case series design
  • Assessment of injury risk associated with stimulant use
  • Focus on methylphenidate's potential effects
  • Overall stimulant use did not decrease fracture or head injury risk
  • Methylphenidate may reduce fracture risk specifically
  • Need for additional preventive injury strategies highlighted

Abstract

Our results indicate that overall stimulant use did not decrease the risk of fracture or head injury in patients with narcolepsy. However, methylphenidate may help prevent fractures. Clinicians should balance the safety and effectiveness of each stimulant with additional preventive strategies for injury.

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Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/69b2584996eeacc4fcec7bcchttps://doi.org/10.1002/phar.70132
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