Baicalein attenuates sepsis-associated encephalopathy by inhibiting ASK1–JNK and NF-κB pathways

Mingming Tan; Boyi Nan; Xiongbin Zhang; Y W X Ou; Hengjie Li; Rongcheng An; Hao Lu; Yong Nan

doi:10.1186/s40001-026-04169-3

March 9, 2026European journal of medical researchOpen Access

Baicalein attenuates sepsis-associated encephalopathy by inhibiting ASK1–JNK and NF-κB pathways

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Key Points

This research aims to explore how baicalein affects sepsis-associated encephalopathy by targeting specific signaling pathways.
Analyzed the effects of baicalein on sepsis-associated encephalopathy in a laboratory setting.
Examined the impact on ASK1–JNK and NF-κB signaling pathways.
Conducted assessments of both anti-inflammatory and neuroprotective effects.
Baicalein significantly reduced markers of inflammation associated with sepsis.
The compound inhibited the activation of ASK1–JNK and NF-κB pathways.
Neuroprotective effects were confirmed, implying potential therapeutic benefits.

Implication

Demonstrates baicalein's ability to reduce sepsis-associated encephalopathy, suggesting it as a promising therapy.

Abstract

Baicalein alleviated SAE through coordinated anti-inflammatory and neuroprotective effects by modulating stress- and inflammation-related signaling pathways, supporting its potential as a therapeutic candidate for SAE.

Discussion

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Cite This Study

Tan et al. (2026) studied this question.

synapsesocial.com/papers/69b2585696eeacc4fcec7de0 https://doi.org/10.1186/s40001-026-04169-3

View Full Paper

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Baicalein attenuates sepsis-associated encephalopathy by inhibiting ASK1–JNK and NF-κB pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

Baicalein attenuates sepsis-associated encephalopathy by inhibiting ASK1–JNK and NF-κB pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

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