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March 12, 2026Clinical Epigenetics1 citationsOpen Access

The m5C demethylase TET1 is identified as a key regulator of scleral remodeling in myopia

SJShichong JiaLYLudi YangPWP. Wei

Key Points

  • This research aims to identify the role of TET1 in scleral remodeling associated with myopia.
  • Analyzed TET1 expression levels in myopic sclera
  • Examined m5C modifications in scleral tissue
  • TET1 expression is significantly altered in myopic sclera
  • m5C modifications are also altered, indicating its role in scleral remodeling

Abstract

Our study reveals substantial alterations in TET1 expression and m5C modification in myopic sclera, providing new insights that may inform the development of novel diagnostic and therapeutic approaches for myopia management.

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Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/69b2585696eeacc4fcec7e1bhttps://doi.org/10.1186/s13148-026-02099-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tet3-mediated DNA demethylation is essential for maintaining the dedifferentiation capacity of mammalian Müller glia2025
  2. 2Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells2026
  3. 3TET1 Regulates Nestin Expression and Human Airway Smooth Muscle Proliferation2024
  4. 4Alterations in N6-Methyladenosine (m <sup>6</sup> A) Modification of mRNA in the Sclera of Form-Deprived Myopic Guinea Pig2026
  5. 5Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-12024 · 6 citations