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March 12, 2026BMC Complementary Medicine and TherapiesOpen Access

Guineenoside B a triterpenoid saponin from Piper guineense (Piperaceae) triggers apoptosis and PI3K/Akt/mTOR inactivation and inhibits metastasis

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Authors

EKEutrophe Le Doux KamtoAOAnne OffermannONOlivier Placide Noté

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Overview

Laboratory study reveals that Guineenoside B induces apoptosis and inhibits metastasis in prostate cancer cells, suggesting its potential as an anticancer agent.

Key Points

  • The aim is to evaluate the anticancer potential of Guineenoside B isolated from Piper guineense against prostate cancer.
  • Isolated three triterpenoid saponins from Piper guineense.
  • Conducted anti-cell growth, proliferation, and clonogenic assays.
  • Investigated apoptosis induction and cell migration/invasion.
  • Assessed key proteins related to cell proliferation and migration.
  • Guin-B showed significant inhibition of PC3 and LNCaP cell growth with IC50 values of 10 µg/mL and 8 µg/mL, respectively.
  • Induced nearly 50% increase in apoptotic cell population at low concentrations.
  • Significant increase in caspase-3 activity was observed.
  • Inhibited migration and invasion of PC3 cells and enhanced cell adhesion.
  • Decreased expression of pAKT, AKT, mTOR, and VEGF proteins was measured after treatment.

Cite This Study

Kamto et al. (2026) studied this question.

synapsesocial.com/papers/69b2588496eeacc4fcec840bhttps://doi.org/10.1186/s12906-026-05329-y
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