BPNet light models for monocytes ATAC-Seq, Krumwiede et al., 2026

Key Points

• To develop and analyze BPNet models for understanding monocyte behavior in different genetic backgrounds.
• Trained BPNet models on wild-type and MORC3 knockout monocytes.
• Utilized ATAC-Seq data to assess chromatin accessibility changes.
• Performed comparisons of accessibility patterns between wild-type and knockout models.
• Highlighted distinct chromatin accessibility in MORC3 knockout monocytes.
• Demonstrated potential regulatory differences due to MORC3 absence.
• Provided insights into monocyte function and regulation.