What does this research mean for the field?

Lilac-colored aggregates (LicAGs) in bone marrow smears are significant indicators of organ involvement and treatment response in patients with amyloid light-chain amyloidosis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the clinical significance of lilac-colored aggregates in patients with amyloid light-chain amyloidosis.

March 12, 2026Amyloid0 citations

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Clinical impact of lilac-colored aggregates on may-Grünwald-Giemsa-stained bone marrow smears in patients with amyloid light-chain amyloidosis

AKAyaka KodamaShinshu University RNRitsuko NakagoshiShinshu University Hospital RORyuto OshitaShinshu University

Key Points

To evaluate the clinical significance of lilac-colored aggregates in patients with amyloid light-chain amyloidosis.
Analyzed bone marrow smears stained with May-Grünwald-Giemsa
Identified and characterized lilac-colored aggregates
Assessed correlation with organ involvement and treatment response
Lilac-colored aggregates were detected in patients with AL amyloidosis
Presence of these aggregates may indicate organ involvement
They serve as potential surrogate markers for treatment response

Abstract

LicAGs are amyloid fibrils, indicating their potential significance in AL amyloidosis, especially when monoclonal immunoglobulins are undetectable. They may also serve as indicators of organ involvement and as surrogate markers for treatment response.

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Clinical impact of lilac-colored aggregates on may-Grünwald-Giemsa-stained bone marrow smears in patients with amyloid light-chain amyloidosis

Key Points

Abstract

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