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March 1, 2026Clinical and Experimental Pharmacology and Physiology

METTL14 Aggravates Sepsis‐Induced Acute Kidney Injury by Promoting Ferroptosis Through m6A Modification of BMAL1

Yishu Wang Yang Li Na Wu Xinyue Xu Xiaoxuan Fan Haifeng Wang

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Key Points

To investigate how METTL14 contributes to sepsis-induced acute kidney injury through ferroptosis mechanisms.
Examined METTL14's effect on BMAL1 m6A modification
Analyzed the degradation of BMAL1 via YTHDF1
Evaluated the impact of ferroptosis on acute kidney injury in a sepsis model
Increased BMAL1 m6A modification observed with elevated METTL14
Enhanced degradation of BMAL1 was linked to YTHDF1 activity
Ferroptosis pathways exacerbated acute kidney injury in sepsis models

Implication

Findings demonstrate METTL14's role in worsening acute kidney injury via ferroptosis in sepsis.

Abstract

METTL14 enhanced BMAL1 m6A modification and promoted YTHDF1-mediated BMAL1 degradation, thereby facilitating ferroptosis and aggravating Sepsis-AKI.

Discussion

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69b258a396eeacc4fcec8782 https://doi.org/10.1111/1440-1681.70107

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1<scp>METTL14</scp> Inhibits Human Lung Microvascular Endothelial Cell From Ferroptosis in Septic Lung Injury by Regulating <scp> N <sup>6</sup> </scp> ‐Methyladenosine‐Modified <scp>ACSL4</scp> Level2025 · 2 citations
2BMAL1 alleviates sepsis-induced acute kidney injury by inhibiting apoptosis, ferroptosis and inflammation2025 · 3 citations
3METTL14‐Mediated N6‐Methyladenosine Exacerbates Acute Lung Injury via USP30/NCOA4‐Dependent FerroptosisOriginal Research · 2026
4METTL3-mediated m6A modification targets the regulation of PCBP1 expression, thereby modulating GPX4 levels and intracellular Fe2⁺ homeostasis to influence ferroptosis and contribute to juvenile sepsis-associated brain injuryOriginal Research · 2026
5Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury2024 · 312 citations

More related papers

SMAD4 Inhibits HO-1–Driven Ferroptosis Through Transcriptional Repression in Sepsis-Associated Acute Kidney Injury2026
METTL1 aggravates sepsis-acute kidney injury by promoting m<sup>7</sup>G methylation of NLRP3-mediated pyroptosis.2025
METTL14 Promotes HK-2 Cell Injury in Diabetic Nephropathy Through the Regulation of THBS2 Expression in an m6A-YTHDF2-Dependent Manner2025

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