Key result
Genomic sequencing of two clinical isolates from Indian pediatric patients with hand, foot, and mouth disease identified them as EV-A71 genotype A (BrCr-like), demonstrating 99.74-99.80% nucleotide identity with the prototype strain.
Observational (n=2)
Yes
This study expands the known diversity of EV-A71 by providing the first near-complete genome sequences of genotype A (BrCr-like) isolates from hand, foot, and mouth disease patients in India.
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Genotype A detection in Indian HFMD cases; leaves open its prevalence, virulence, and need for expanded surveillance.
We report near-complete (~7.4 kb) genomes of two human enterovirus A71 (EV-A71) isolates from Rajasthan (2022) and Mizoram (2024), India. Genotyping and phylogenetic analyses placed both within genotype A (BrCr-like), expanding EV-A71 diversity associated with hand, foot, and mouth disease in India.
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Jagtap et al. (2026) conducted an observational in Hand, foot, and mouth disease (n=2). Human enterovirus A71 (EV-A71) infection was evaluated on Genomic sequence and phylogenetic classification of isolated virus. Genomic sequencing of two clinical isolates from Indian pediatric patients with hand, foot, and mouth disease identified them as EV-A71 genotype A (BrCr-like), demonstrating 99.74-99.80% nucleotide identity with the prototype strain.
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