Immunogenetic Interplay of IL-6 and IL-6R Genes Variants and Circulating IL-6 Levels in Toxoplasma gondii-infected Women with Recurrent Pregnancy Loss. | Synapse
Immunogenetic Interplay of IL-6 and IL-6R Genes Variants and Circulating IL-6 Levels in Toxoplasma gondii-infected Women with Recurrent Pregnancy Loss.
Key Points
The study aims to explore the association between IL-6 and IL-6R gene variants and recurrent pregnancy loss (RPL) in women infected with Toxoplasma gondii.
Assessment of IL-6 -174G/C and -597G/A polymorphisms in women
Evaluation of IL-6R A/C gene variants
Measurement of circulating IL-6 levels in the participants
IL-6 gene variants were significantly associated with an increased risk of RPL in the studied population.
Altered circulating IL-6 levels were linked to specific gene polymorphisms, impacting bioavailability.
The presence of IL-6R variants correlated with heightened IL-6 levels in infected individuals.
Abstract
The IL-6 gene -174G/C, -597G/A, and IL-6R gene A/C polymorphisms play significant roles in RPL in women infected with T. gondii, and change IL-6 bioavailability.