Low-dose citrate infusion maintained circuit survival similar to standard dosing while reducing citrate-related complications such as hypocalcemia and metabolic alkalosis.
Cohort (n=127)
No
Does a low initial citrate infusion dose reduce metabolic complications without compromising circuit survival compared to a standard dose in critically ill children undergoing continuous kidney replacement therapy?
A low initial citrate infusion dose for regional citrate anticoagulation in pediatric CKRT maintains circuit survival while significantly reducing the risk of metabolic complications like citrate accumulation and hypocalcemia.
Absolute Event Rate: 49.5% vs 51%
p-value: p=0.857
Administering a low CID when initializing RCA significantly reduces the likelihood of citrate-related complications while maintaining anticoagulant efficacy.
Duyu et al. (Tue,) conducted a cohort in Continuous kidney replacement therapy (n=127). Low-dose citrate infusion vs. Standard citrate dosing was evaluated on Circuit survival (CS) (p=0.857). Low-dose citrate infusion maintained circuit survival similar to standard dosing while reducing citrate-related complications such as hypocalcemia and metabolic alkalosis.