Medium-ring benzolactams via nickel-catalyzed denitrogenative re-cyclization of benzotriazinones with di(pseudo)haloalkanes

Key Points

• The aim is to develop a new method for synthesizing medium-ring benzolactams from benzotriazinones.
• Utilized nickel catalysis to initiate the denitrogenative re-cyclization process.
• Conducted intermolecular cross-electrophile coupling with di(pseudo)haloalkanes.
• Employed Mn-mediated intramolecular N-alkylation to form target compounds.
• Successfully synthesized a variety of tetrahydrobenzoazepin-1-ones and tetrahydrobenzoazocin-1(2H)-ones.
• Demonstrated effectiveness of nickel as a catalyst in the re-cyclization process.