Porcine reproductive and respiratory syndrome virus exploits ESCRT-II subunit EAP20 for entry and replication.

PRRSV remains one of the most economically significant pathogens in the global swine industry. Current control strategies are largely hindered because PRRSV pathogenesis has not been fully elucidated. In this study, we identified EAP20, a core subunit of ESCRT-II, as a multifaceted proviral factor that participated in PRRSV entry and replication. These findings provide new insights into the interplay between PRRSV and the host ESCRT machinery, laying a foundation for the development of more effective strategies for PRRS control.