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March 12, 2026Scientific ReportsOpen Access

Regulation of the AKT/P53 signaling pathway by translated control tumor protein inhibits apoptosis and promotes hyperplasia of the mammary glands

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Authors

MMMu-Yuan MaSWSheng WangXJXue-Mei Jin

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Overview

Demonstrates TCTP's role in apoptotic inhibition and hyperplasia in mammary glands, suggesting a potential treatment pathway.

Key Points

  • This research aims to investigate how TCTP influences mammary gland hyperplasia through the AKT/P53 pathway.
  • Developed TCTP knockout and overexpression mouse models
  • Induced hyperplasia using estrogen and progesterone
  • Performed H&E staining and evaluated hormone receptor expression
  • Analyzed expression levels of TCTP, p-AKT, P53, and related indicators in breast tissues
  • HMG cKO group showed reduced ductal dilation and milk gland numbers
  • HMG KI group exhibited significant mammary gland hyperplasia
  • Decreased levels of Ki67, E2, FSH, LH, ERα, PR, and several other markers in cKO
  • Increased levels of PROG, ERβ, P53, Bax, and P27 in cKO group
  • Findings confirm TCTP's role in inhibiting apoptosis and promoting cell cycle progression

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/69b25b5496eeacc4fcec9f26https://doi.org/10.1038/s41598-026-43565-x
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