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March 12, 2026The Journal of Immunology

Microalgal delivery of recombinant fish interferon modulates gut microbiota and enhances antiviral immunity in fish

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Authors

GLGao-peng LiuZLZhuo-Cong LiQLQiyun Li

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Overview

Research reveals that recombinant interferon modulates gut microbiota and boosts immunity in fish, suggesting a new aquaculture strategy.

Key Points

  • Evaluate the effect of recombinant interferon delivery via microalgae on gut microbiota and antiviral immunity in fish.
  • Constructed recombinant interferon strain using Synechococcus sp. PCC 7002.
  • Administered Rec-IFN diet to gibel carp and zebrafish.
  • Analyzed intestinal microbiome and transcriptomic responses post-infection.
  • Rec-IFN diet promoted beneficial bacteria while reducing pathogens in gibel carp.
  • In zebrafish, the diet increased species richness and reduced Vibrio.
  • Enhanced host interferon response led to reduced viral load and mortality.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69b25b5496eeacc4fcec9f57https://doi.org/10.1093/jimmun/vkaf304
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