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March 12, 2026The Journal of Clinical Endocrinology & Metabolism2 citationsOpen Access

Early pregnancy biomarkers of inflammation and metabolic regulation in polycystic ovary syndrome

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SASimon AlesiTMTaitum MasonSEStacey J. Ellery

Key Points

  • The aim is to investigate the role of inflammation and metabolic regulation biomarkers in early pregnancy among women with PCOS.
  • Measured concentrations of MCP1 and FABP4 in early pregnancy
  • Analyzed associations between biomarkers and pregnancy outcomes
  • Assessed maternal adiposity levels
  • MCP1 and FABP4 levels were higher among women with PCOS in early pregnancy
  • No significant modification of pregnancy outcomes by these biomarkers
  • Further research is necessary to explore metabolic pathways in this context.

Abstract

MCP1 and FABP4 concentrations were elevated in early pregnancy among women with PCOS, largely reflecting maternal adiposity. These markers did not modify associations between PCOS and pregnancy outcomes. Larger longitudinal studies are needed to clarify underlying inflammatory and metabolic pathways.

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Cite This Study

Alesi et al. (2026) studied this question.

synapsesocial.com/papers/69b25b7196eeacc4fceca253https://doi.org/10.1210/clinem/dgag098
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