Does the assessment of rare and common genetic variants improve hypertrophic cardiomyopathy risk prediction beyond clinical factors in the general population?
General population in a national biobank
Assessment of rare and common genetic variants
Clinical factors alone
Hypertrophic cardiomyopathy (HCM) susceptibility and risk prediction
Incorporating rare and common genetic variants improves the prediction of hypertrophic cardiomyopathy risk beyond standard clinical factors.
Both rare and common genetic variants contribute substantially to HCM susceptibility in the general population and improve HCM risk prediction beyond that achieved with clinical factors.
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Kiran J. Biddinger
Heart Failure & Transplant
Sean J. Jurgens
Electrophysiology
Dimitri J. Maamari
Broad Institute
JAMA Cardiology
Harvard University
Princeton University
Massachusetts General Hospital
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Biddinger et al. (Wed,) studied this question.
synapsesocial.com/papers/69b30947293a18c204b3f565 — DOI: https://doi.org/10.1001/jamacardio.2022.1061