DPP-4 promotes aortic valve calcification by inhibiting IGF-1 signaling in valvular interstitial cells, identifying it as a potential therapeutic target for calcific aortic valve disease.
DPP-4-dependent insulin-like growth factor-1 inhibition in VICs contributes to aortic valve calcification, suggesting that DPP-4 could serve as a potential therapeutic target to inhibit calcific aortic valve disease progression.
Choi et al. (Thu,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: