February 9, 2017CirculationOpen Access

Dipeptidyl Peptidase-4 Induces Aortic Valve Calcification by Inhibiting Insulin-Like Growth Factor-1 Signaling in Valvular Interstitial Cells

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Population

Valvular interstitial cells (VICs)

Design

Preclinical

Authors

BCBongkun ChoiUlsan College SLSahmin LeeStructural Heart Disease SKSang-Min KimUlsan College

Discussion

Member takes

Implication

DPP-4 inhibition merits exploration in calcific aortic valve disease; leaves open human therapeutic translation.

Structured PICO

Population

Valvular interstitial cells (VICs)

Outcome

Aortic valve calcification

DPP-4 promotes aortic valve calcification by inhibiting IGF-1 signaling in valvular interstitial cells, identifying it as a potential therapeutic target for calcific aortic valve disease.

Cite This Study

Choi et al. (2017) studied this question.

synapsesocial.com/papers/69b31ef1033832e42976e193 https://doi.org/10.1161/circulationaha.116.024270

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Dipeptidyl Peptidase-4 Induces Aortic Valve Calcification by Inhibiting Insulin-Like Growth Factor-1 Signaling in Valvular Interstitial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dipeptidyl Peptidase-4 Induces Aortic Valve Calcification by Inhibiting Insulin-Like Growth Factor-1 Signaling in Valvular Interstitial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider