Retrospective study examines allergen-specific IgE profiles in children with eczema and urticaria, suggesting age-based risk assessment.
Key Points
This study aims to explore sensitization patterns of allergen-specific immunoglobulin E (sIgE) in children diagnosed with eczema and urticaria, while considering the effects of age.
Conducted a single-center, retrospective cross-sectional study
Analyzed serum samples from 4,925 children with eczema or urticaria
Measured sIgE levels using fluorescence immunoassay
Compared group differences using chi-square tests and Spearman correlation analysis
Overall sIgE positive rate was 58.05%, with food allergens showing a higher rate of 52.93% compared to 14.05% for inhalants
Children under 3 years had higher sensitization to food allergens, while older children had increased rates for inhaled allergens
Eczema patients had a significantly higher positivity for food allergens compared to urticaria patients
Inhaled allergens showed higher sensitization in urticaria compared to eczema; low-level sIgE was common, high-grade positivity was rare
sIgE to food correlated positively with eosinophil counts in eczema, while inhalant allergens correlated with hemoglobin levels in urticaria