Expression of Concern: Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: Possible role of the Akt/GSK3β signaling pathway

Q: What does this research mean for the field?

Hydrogen-rich saline has a neuroprotective effect against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

The PLOS One Editors

doi:10.1371/journal.pone.0344335

March 9, 2026PLoS ONEOpen Access

Expression of Concern: Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: Possible role of the Akt/GSK3β signaling pathway

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Key Points

This research aims to explore how hydrogen-rich saline can protect the brain after subarachnoid hemorrhage and its possible mechanisms.
Review of literature on hydrogen-rich saline and its effects on brain injury.
Examined the Akt/GSK3β signaling pathway in relation to neuroprotection and apoptosis.
Considered findings from previous studies on subarachnoid hemorrhage.
Hydrogen-rich saline demonstrated potential neuroprotective effects in brain injury.
Evidence suggests modulation of the Akt/GSK3β pathway may play a key role in reducing apoptosis.
Findings support the hypothesis that hydrogen-rich saline can mitigate neurologic damage.

Implication

Expression of concern highlights hydrogen-rich saline's neuroprotective effects in subarachnoid hemorrhage, suggesting implications for treatment.

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Cite This Study

The PLOS One Editors (2026) studied this question.

synapsesocial.com/papers/69b3aaa802a1e69014ccb6c3 https://doi.org/10.1371/journal.pone.0344335

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Expression of Concern: Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: Possible role of the Akt/GSK3β signaling pathway

Key Points

Implication

Discussion

Cite This Study

Expression of Concern: Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: Possible role of the Akt/GSK3β signaling pathway

Key Points

Implication

Discussion

Cite This Study

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