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March 13, 2026Frontiers in Cell and Developmental BiologyOpen Access

The neural niche in cancer: mechanistic insights into tumor–neuron–immune crosstalk and therapeutic opportunities

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Authors

NANeşe AyşitEAEsra AltintasFAFulya Üstün Alkan

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Overview

Analysis reveals that tumor-neuron-immune interactions influence cancer progression and suggest new therapeutic strategies.

Key Points

  • This review aims to explore the role of the neural niche in cancer and its interaction with tumor and immune cells.
  • Reviewed existing literature on tumor-neuron-immune crosstalk
  • Analyzed mechanisms of neurotrophic factors and neurotransmitters
  • Discussed impacts of chronic stress and neuroendocrine activation
  • Identified key neurotrophic factors influencing tumor and immune cell behavior
  • Established the link between perineural invasion and cancer outcomes
  • Proposed therapeutic approaches targeting neuroimmune interactions

Cite This Study

Ayşit et al. (2026) studied this question.

synapsesocial.com/papers/69b3aad702a1e69014ccb8d5https://doi.org/10.3389/fcell.2026.1667459
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