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March 9, 2026iMetaOpen Access

Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells

Bin Ye Zhen Wang Yinqi Bai Yong Zhang Rui Zhang Jingru Lian Xia Liu Yu Zhang Zhiyuan Xu Lan Yang Haiman Jin Fang Chen Zhihao Xie Ping Zhou Jingru Tan Yu Zeng Changzheng Du Yue Min Xiaomin Ni Jingxian Duan M. Li H. J. Yang Yi Cai Hongyan Wu Catherine C. Liu Jing Cai Yi Lu Jian Zhang Hao Wu Hairong Zheng Ya Liu Xin Hong Hao Yu

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Key Points

The study aims to develop a method for identifying and tracing circulating tumor cells (CTCs) using chromatin unwinding state (CUS) features from single-cell sequencing data.
Developed panCTC, an attention-based neural network for CTC identification.
Analyzed single-cell transcriptomic data without enrichment from 5 mL of peripheral blood.
Evaluated model performance with over 660,000 cells across 42 datasets.
panCTC achieved high sensitivity (0.962) and specificity (1.0) in CTC detection.
Demonstrated superior performance over existing methods with a lower false positive rate.
Identified CTC molecular features associated with disease progression in multiple cancer types.

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Implication

Novel algorithm identifies and traces circulating tumor cells in blood, suggesting advances in cancer monitoring.

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Cite This Study

Ye et al. (2026) studied this question.

synapsesocial.com/papers/69b3aad702a1e69014ccb900 https://doi.org/10.1002/imt2.70119

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Abstract 7506: Comprehensive mutational profile of true single circulating tumor cells compared with CtDNA in advanced pancreatic adenocarcinoma2024
2A mass cytometry‐based lens on <scp>DNA</scp> damage repair in circulating tumor cells from breast cancer patients2025
3Abstract 1068: Combining circulating tumor cells and cancer associated macrophage-like cells enhances risk stratification models in pan-cancer metastatic diseaseOriginal Research · 2026
4The phenotypic heterogeneity of tumor-derived cells in the bloodstream of pancreatic cancer patientsOriginal Research · 2026
5Abstract 2303: Identifying and stratifying circulating tumor cell cluster subtypes in metastatic breast cancer patients and evaluating their clinical outcomes2024

CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches2024
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Single-cell circulating tumor cell genomics of KRAS-independent oncogenic sub-populations and longitudinal clonal evolution in metastatic pancreatic adenocarcinoma.2026
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