Mechanistic study of swertiamarin in treating ulcerative colitis by regulating YAP-mediated Wnt and Notch pathways for intestinal stem cell repair

Key Points

• The research aims to investigate how swertiamarin regulates YAP-mediated pathways to treat ulcerative colitis.
• Examined the effects of swertiamarin on intestinal stem cells (ISCs)
• Analyzed activation of YAP, Wnt, and Notch pathways
• Assessed mucosal barrier integrity restoration
• Swertiamarin increased proliferation and differentiation of intestinal stem cells
• Improved mucosal barrier integrity was observed
• YAP-mediated pathways were significantly activated in response to treatment