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A case report demonstrates tamoxifen therapy reduces symptoms of gigantomastia in a child with PASH, suggesting a non-surgical treatment option.
Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign breast lesion in children. We report a 10-year-old girl with hormonally driven gigantomastia and recurrent mastitis, interpreted as a secondary inflammatory complication of rapid breast enlargement. Treatment with oral tamoxifen led to arrest of breast growth and resolution of inflammatory symptoms. This case supports tamoxifen as a potential non-surgical option for hormonally driven pediatric gigantomastia associated with PASH.
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Coslovich et al. (2026) studied this question.
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