Copper-Catalyzed Amino-alkoxycarbonylation of Unactivated Alkenes: Synthesis of β-Amino Esters via Primary Tosyl Amidyl Radical.

β-Amino acids serve as essential motifs in a wide array of bioactive compounds, pharmaceuticals, and natural products, playing a crucial role in the development of peptides and peptidomimetics. Transition-metal-catalyzed carbonylative functionalization represents an ideal strategy for synthesizing carbonyl-containing compounds. In this context, we disclose a primary tosyl amidyl radical initiated 1,2-amino-alkoxycarbonylation of unactivated alkenes, which offers a straightforward and efficient approach to synthesize β-amino acid derivatives.