What question did this study set out to answer?

To investigate the relationship between polyp recurrence timing and STK11 mutation status in pediatric Peutz-Jeghers syndrome.

March 13, 2026Journal of Pediatric Gastroenterology and Nutrition0 citations

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Distinct polyp recurrence timing and STK11 mutation status underlie clinical heterogeneity in pediatric Peutz–Jeghers syndrome

LYLingzhi YuanCentral South University QTQin TongCentral South University KXKang XieSouth China Agricultural University

Key Points

To investigate the relationship between polyp recurrence timing and STK11 mutation status in pediatric Peutz-Jeghers syndrome.
Analyzed polyp recurrence intervals in pediatric patients
Compared STK11-positive and -negative groups
Assessed the STK11 mutation landscape in the cohort
Identified distinct clinical profiles based on recurrence intervals
Uncovered differences between STK11-positive and -negative cases
Provided a genomic resource that enhances understanding of disease mechanisms

Abstract

This study reveals distinct clinical profiles across polyp recurrence intervals and between STK11-positive and -negative patients, while delineating the STK11 mutation landscape in pediatric PJS. These findings provide the genomic resource for pediatric PJS, offering critical insights into disease mechanisms and clinical management.

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Distinct polyp recurrence timing and STK11 mutation status underlie clinical heterogeneity in pediatric Peutz–Jeghers syndrome

Key Points

Abstract

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