Identifies DNA methylation signatures that predict survival in smokers with lung squamous cell carcinoma, suggesting potential biomarkers.
This study identified a subtype-specific DNA methylation signature that robustly distinguishes LUAD and LUSC and is associated with early survival among ever-smokers with LUSC. These findings highlight biologically meaningful epigenetic patterns that may contribute to histology-specific tumor behavior and provide a foundation for future mechanistic and biomarker development studies.
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Lim et al. (2026) studied this question.
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