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March 13, 2026AntioxidantsOpen Access

Natural Bioactive Peptides from Tree Peony Flowers: Multifunctional Effects on Skin Antioxidation, Wrinkle Reduction, Moisturization, and Melanin Inhibition

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Authors

YLYu LiuRZRuofei ZhengLZLinyue Zhong

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Overview

This research evaluates the skin health effects of tree peony flower protein hydrolysates, suggesting promising cosmetic applications.

Key Points

  • This research aims to explore the multifunctional effects of protein hydrolysates from tree peony flowers on skin health.
  • Protein hydrolysates were prepared via enzymatic hydrolysis and ultrafiltration.
  • Peptide sequences were identified using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
  • Safety evaluations were conducted using CCK-8 assay in HaCaT and B16F10 cells.
  • Functional assays assessed antioxidant, anti-wrinkle, moisturizing, and whitening effects of TPFP.
  • TPFP showed no significant cytotoxic effects in keratinocytes or melanoma cells.
  • It inhibited UVB-induced reactive oxygen species (ROS) production and improved SOD and CAT activities.
  • TPFP prevented UVB-induced loss of pro-collagen I and restored hyaluronic acid levels.
  • TPFP reduced melanin synthesis by downregulating tyrosinase and related proteins in stimulated melanoma cells.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69b3ab6e02a1e69014ccc540https://doi.org/10.3390/antiox15030350
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chemical profiling and targeted anti-photoaging mechanisms of wild tree peony stem and leaf extracts2026
  2. 2Optimization of Enzymatic Extraction Process for <i>Peony lactiflora</i> Seed and Its Application in Skin Care2025
  3. 3Artificial Neural Network-Guided Discovery of Antioxidant Peptides from Peony (Paeonia ostii) Seed Meal: Peptidomics, Molecular Mechanism, and Cellular Validation2026
  4. 4Novel Dual-Action Whitening Peptides Derived from Tea Protein Hydrolysates2025
  5. 5Multidisciplinary Bioanalytical Approach to Assess the Anti-Aging Properties of Flower Petals—A Promising Sustainable Cosmetic Ingredient2025