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March 13, 2026Journal of Antimicrobial Chemotherapy

Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study

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To assess the pharmacokinetics of meropenem in critically ill adults receiving ECMO.
Analyzed meropenem dosing in critically ill patients on ECMO.
Administered 1 g doses every 8 hours as a continuous infusion.
Evaluated safety and efficacy of this dosing strategy.
Meropenem showed safe pharmacokinetics in the studied population.
Efficacy maintained with continuous infusion dosage in ECMO patients.
No significant adverse effects reported related to the drug.

Implication

Population pharmacokinetics analysis reveals safe and effective meropenem dosing in critically ill adults on ECMO, highlighting treatment viability.

Abstract

A meropenem dose of 1 g every 8 h as continuous infusion is safe and efficacious in most critically ill patients receiving ECMO with or without concomitant RRT.

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Cite This Study

Abdul–Aziz et al. (2026) studied this question.

synapsesocial.com/papers/69b3ab9102a1e69014ccc97d https://doi.org/10.1093/jac/dkag090

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Implication

Population pharmacokinetics analysis reveals safe and effective meropenem dosing in critically ill adults on ECMO, highlighting treatment viability.

Abstract

A meropenem dose of 1 g every 8 h as continuous infusion is safe and efficacious in most critically ill patients receiving ECMO with or without concomitant RRT.

Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study

Key Points

Implication

Abstract

Discussion

Cite This Study

Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study

Key Points

Implication

Abstract

Discussion

Cite This Study

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