Categorization of Patients with Peripheral Artery Disease by Charlson Comorbidity Index.

PAD patients' comorbidity burden increased during the observational period between 2005 and 2022 in Germany. Higher comorbidity burden mirrored by higher CCI class was associated with an approximately 10-fold increased risk for MACCE and in-hospital mortality. Physicians have to be aware for the impact of comorbidity burden and optimization of the comorbidities is an important focus to improve outcomes and prevent complications.